Pharmacokinetic-pharmacodynamic Modeling of Antihypertensive Drugse
نویسندگان
چکیده
Knowledge of pharmacokinetic-pharmacodynamic (PK/PD) properties of antihypertensive drugs may optimize drug therapy of hypertension. PK/PD modeling in clinical research could contribute in drug development and clinical practice in several aspects, including an evaluation of the efficacy and safety of antihypertensive agents, enhancement of information during the development process, identification of factors that contribute to drug response variability, by allowing a rapid identification of poor or non-responders and by helping to determine optimal antihypertensive drug and dose requirements in each hypertensive patient. There are some limitations in PK/PD modeling of antihypertensive drugs in the clinical setting, including application of inadequate pharmacodynamic models and the inability to study large doses of antihypertensive drugs in order to determine the complete pharmacodynamic range of their antihypertensive effect. The aim of the present review is to describe the current knowledge of PK/PD modeling of antihypertensive drugs in basic and clinical research and its future applications.
منابع مشابه
Drug interactions in hypertension.
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